Which grade indicates that the USPSTF recommends against a service?

The grade that indicates the USPSTF recommends against a service is Grade D. This designation is assigned to services or interventions for which evidence suggests there is no net benefit or where potential harms outweigh potential benefits. When a service receives a Grade D recommendation, it implies that the task force believes routine use of that service should be discouraged in the population it pertains to.

On the other hand, a Grade A recommendation signifies that there is strong evidence supporting the benefits of a service, and it should be offered or provided routinely. Grade C indicates that the service may be offered depending on the individual situation, especially when benefits and harms are closely matched. Grade I indicates insufficient evidence to make a recommendation either for or against a service, suggesting more research is needed. Thus, Grade D is the clear indicator of a recommendation against a specific service.