What does an 'I' grade in USPSTF recommendations suggest?

An 'I' grade in USPSTF recommendations indicates that there is insufficient evidence to determine the benefits and harms of a specific preventive service. This grade serves as a signal to clinicians and patients that there is a lack of conclusive information to support a clear recommendation for or against the use of the service. Consequently, when a service receives an 'I' grade, it implies that more research is needed to evaluate its effectiveness, safety, and overall role in preventive healthcare.

This classification encourages ongoing research to gather data that may lead to more definitive recommendations in the future. By contrast, other grades indicate either a clear recommendation for or against a service based on adequate evidence, or suggest that a service is universally beneficial or mandated under certain circumstances. However, the 'I' grade reflects uncertainty, prompting clinicians to consider individual patient situations and engage in shared decision-making regarding the service.